gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-GD2 mAb binds GD2 on tumor cells; its Fc engages CD16 on NK cells to drive ADCC, activates complement for CDC, and opsonizes cells for macrophage ADCP, resulting in killing of GD2+ cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Glycolipid antigen on neuroblastoma cell surface
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06631391
disease_id_num_tar_ref
452
drug_id_num_tar_ref
1271