gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Engineered TCR-T cells recognize the tumor peptide–HLA class I complex and directly kill target cells via cytotoxic synapse formation with perforin/granzyme-mediated apoptosis (and Fas–FasL), with cytokine-supported cytotoxicity.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Peptide-HLA (pMHC) complex on tumor cells; exact peptide and HLA allele are therapy-specific
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06541327
disease_id_num_tar_ref
5328
drug_id_num_tar_ref
14504