gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
BC3195 binds CDH3 on tumor cells, is internalized, and releases MMAE, which inhibits tubulin polymerization, causing G2/M arrest and apoptosis (with possible bystander killing). Tubulin is the intracellular payload target, not the selection antigen.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
payload MMAE binds tubulin (vinca site) to inhibit microtubule polymerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06548672
disease_id_num_tar_ref
5373
drug_id_num_tar_ref
14622