gene_symbol
TNFRSF17
hgnc_id
HGNC:11913
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
BCMA-specific CAR T cells bind BCMA on target cells, become activated, form an immunologic synapse, and kill via perforin/granzyme release and Fas–FasL–mediated apoptosis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Extracellular domain on plasma cells and multiple myeloma cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06041815
disease_id_num_tar_ref
5443
drug_id_num_tar_ref
14784