gene_symbol
CLDN18
hgnc_id
HGNC:2039
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds CLDN18.2 on tumor cells, is internalized, and releases MMAE intracellularly, disrupting microtubules to cause G2/M arrest and apoptosis of CLDN18.2-expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
On
hla_specific
Off
gated
Off
other_modifier
A2 isoform (18.2) targeted by the antibody component
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05702229
disease_id_num_tar_ref
5462
drug_id_num_tar_ref
14841