gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC binds CLDN18.2 on tumor cells, is internalized, and releases MMAE, which binds beta-tubulin to block microtubule polymerization, causing G2/M arrest and apoptosis; beta-tubulin expression alone does not make cells targets for killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Direct target of released payload MMAE at the vinca-binding site; multiple beta-tubulin isoforms may be engaged
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05702229
disease_id_num_tar_ref
5462
drug_id_num_tar_ref
14841