gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
A166 targets HER2, is internalized, and releases an auristatin payload that binds beta‑tubulin to disrupt microtubules and induce mitotic arrest/apoptosis. Beta‑tubulin is not the targeted antigen; cytotoxicity requires HER2-mediated delivery.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Auristatin (duostatin-5) payload binds β-tubulin (vinca site) to inhibit microtubule polymerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06968585
disease_id_num_tar_ref
5471
drug_id_num_tar_ref
14869