gene_symbol
FCGRT
hgnc_id
HGNC:3621
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
FcRn is not the antigen targeted for killing; LS mutations increase FcRn-mediated recycling/half-life only. Killing occurs only when the antibody binds HIV-1 Env on infected cells, enabling Fc-mediated ADCC/ADCP—not via FcRn.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
LS Fc mutations increase affinity; extends serum half-life
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05300035
disease_id_num_tar_ref
466
drug_id_num_tar_ref
1301