gene_symbol
FCGR2A
hgnc_id
HGNC:3616
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
3BNC117-LS binds HIV-1 Env gp120 on infected cells and recruits FcγR-expressing effector cells (e.g., via CD16/CD32a) to mediate ADCC/ADCP against gp120+ infected cells. Cells expressing CD32a are effector cells and are not targeted or killed by the antibody.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Mediates ADCP on monocytes/macrophages
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05300035
disease_id_num_tar_ref
466
drug_id_num_tar_ref
1301