gene_symbol
TNFRSF17
hgnc_id
HGNC:11913
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-BCMA CAR T cells bind BCMA on target cells; CAR signaling (CD3ΞΆ with costimulation) activates T cells to kill BCMA+ cells via perforin/granzyme release and death-receptor pathways.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Dual-epitope binding to extracellular domain of membrane BCMA
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06574126
disease_id_num_tar_ref
5510
drug_id_num_tar_ref
14998