gene_symbol
HLA-A
hgnc_id
HGNC:4931
binding_type
receptor ligand recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Intratumorally delivered CMV/EBV peptides load onto HLA-A*02:01 on tumor cells; pre-existing virus-specific CD8+ T cells recognize the peptide–HLA complex and kill the presenting cells via perforin/granzyme (and Fas–FasL) cytotoxicity. Killing requires peptide presentation on HLA-A*02:01.
enzyme_product
Off
epitope
Off
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
Allele-restricted peptide loading on tumor and dendritic cells; beta-2 microglobulin–associated MHC-I complex
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05338658
disease_id_num_tar_ref
5543
drug_id_num_tar_ref
15084