gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Intratumorally delivered CMV pp65 peptide binds MHC-I (HLA-A*02:01) on cells; pre-existing CMV-specific CD8+ T cells recognize peptide–MHC and lyse those cells via perforin/granzyme (and Fas–FasL) cytotoxicity.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Viral peptide antigens presented by HLA-A*02:01 to recruit CMV-specific memory CD8+ T cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05338658
disease_id_num_tar_ref
5543
drug_id_num_tar_ref
15084