gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The vaccine primes and expands neoantigen-specific CD8+ T cells, which recognize neoantigen–MHC I on tumor cells and kill them via perforin/granzyme-mediated cytolysis (and Fas–FasL apoptosis).
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
CD8+ T-cell epitopes; personalized poly-neoepitope mixture
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06353646
disease_id_num_tar_ref
5562
drug_id_num_tar_ref
15142