gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The vaccine delivers neoantigen mRNA to dendritic cells, which present peptides on MHC I/II and prime neoantigen-specific CD8+ and CD4+ T cells. These T cells then recognize the neoantigen peptides on tumor cells (including MHC II–presented) and kill them via perforin/granzyme and Fas–FasL pathways.
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
CD4+ T-cell epitopes; personalized poly-neoepitope mixture
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06353646
disease_id_num_tar_ref
5562
drug_id_num_tar_ref
15142