gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Autologous TILs recognize the tumor neoantigen peptide–HLA class I complex via their native TCR, then kill the target cell by cytotoxic granule release (perforin/granzymes) and Fas–FasL–mediated apoptosis.
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
CD8+ TCR-restricted pMHC-I; patient-specific 8–11 aa peptides
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06566092
disease_id_num_tar_ref
471
drug_id_num_tar_ref
1313