gene_symbol
CA12
hgnc_id
HGNC:1371
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Lutetium-177–labeled 6A10 Fab binds CA XII on tumor cells and delivers beta radiation to the bound cells, causing localized DNA damage (double‑strand breaks) and cell death; some crossfire to nearby cells may occur.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Membrane-bound extracellular domain on glioblastoma cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05533242
disease_id_num_tar_ref
5634
drug_id_num_tar_ref
15321