gene_symbol
CD24
hgnc_id
HGNC:1645
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-CD24 IgG binds CD24 on tumor cells, blocks the CD24–Siglec-10 checkpoint and engages Fcγ receptors on effector cells, triggering macrophage phagocytosis (ADCP) and NK cell ADCC of CD24+ cells; complement lysis may also contribute.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Blocks CD24–SIGLEC10 interaction on macrophages; Fc-dependent effector functions possible (ADCC/ADCP)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05985083
disease_id_num_tar_ref
5638
drug_id_num_tar_ref
15328