gene_symbol
FCGR1A
hgnc_id
HGNC:3613
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
TRL345 binds HCMV gB on virions/infected cells; its Fc engages Fcγ receptors (including CD64) on effector cells to mediate ADCC/complement against gB+ infected cells. CD64+ cells serve as effectors, not targets, and are not killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc-mediated effector engagement on macrophages/monocytes
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05408091
disease_id_num_tar_ref
5647
drug_id_num_tar_ref
15343