gene_symbol
FCGR2A
hgnc_id
HGNC:3616
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
TRL345 binds HCMV gB on virions/infected cells and recruits FcγR-bearing effectors (via its Fc) to mediate ADCC/complement against gB-expressing infected cells. CD32A+ cells serve as effector cells, not targets, and are not killed by the drug.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc-mediated effector engagement
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05408091
disease_id_num_tar_ref
5647
drug_id_num_tar_ref
15343