gene_symbol
CD70
hgnc_id
HGNC:11937
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CD70-specific CAR-NKT cells recognize CD70 on target cells and directly kill them via CAR-triggered cytolytic degranulation (perforin/granzyme-mediated apoptosis).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Membrane-bound TNFSF7 (CD27 ligand); HLA-independent CAR binding
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06182735
disease_id_num_tar_ref
5746
drug_id_num_tar_ref
15620