gene_symbol
CD2
hgnc_id
HGNC:1639
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Unconjugated anti-CD2 IgG binds CD2 on T and NK cells; its Fc recruits immune effectors and complement, causing ADCC and CDC-mediated depletion of CD2+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Blocks CD2–CD58 (LFA-3) costimulatory/adhesion interaction; targets CD2 on T lymphocytes and NK cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06025110
disease_id_num_tar_ref
5769
drug_id_num_tar_ref
15674