gene_symbol
TNFRSF17
hgnc_id
HGNC:11913
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
BCMA-specific CAR T cells bind BCMA on target cells and, upon CAR (CD3ζ±costim) activation, kill them via perforin/granzyme-mediated lysis and apoptosis (with additional Fas/FasL and cytokine-mediated cytotoxicity).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Plasma cell/multiple myeloma antigen; MHC-independent CAR recognition
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06377059
disease_id_num_tar_ref
5814
drug_id_num_tar_ref
15794