gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Bispecific binds CD3 on T cells and a tumor antigen on cancer cells, activating T cells to kill the tumor via perforin/granzyme; CD3+ T cells themselves are not killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
T-cell activation trigger via CD3/TCR complex
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06377059
disease_id_num_tar_ref
5814
drug_id_num_tar_ref
15795