gene_symbol
TNFRSF4
hgnc_id
HGNC:11918
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The IgG1 antibody binds OX40 on activated T cells and its Fc engages Fcγ receptors on effector cells (e.g., NK cells), triggering Fc‑enhanced ADCC that lyses/depletes OX40+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Blocks OX40–OX40L interaction and mediates Fc-enhanced ADCC against OX40+ T cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06224192
disease_id_num_tar_ref
5843
drug_id_num_tar_ref
15867