gene_symbol
TACSTD2
hgnc_id
HGNC:11530
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
TROP2-specific CAR on NK cells binds TROP2 on target cells, activating NK cytotoxicity with degranulation (perforin/granzyme-mediated apoptosis) and death-receptor pathways; IL-15 supports NK activity and persistence.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
CAR antigen on tumor cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06358430
disease_id_num_tar_ref
491
drug_id_num_tar_ref
1351