gene_symbol
TNFSF7
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR engagement of CD70 activates CAR‑T cells to release perforin and granzymes (and other cytotoxic pathways), inducing apoptosis/lysis of CD70‑expressing cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface TNF superfamily ligand; CAR scFv binds extracellular domain on tumor cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06215950
disease_id_num_tar_ref
5870
drug_id_num_tar_ref
15934