gene_symbol
IGHG1
hgnc_id
HGNC:5525
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
TROP2-CAR-NK cells specifically recognize TROP2, not human IgG1 Fc. They kill TROP2-positive cells via NK degranulation (perforin/granzyme) and cytokine-mediated cytotoxicity; cells bearing IgG1 Fc are not targeted.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Engaged via NK-cell FcγRIIIa (CD16A) to mediate ADCC in the presence of IgG1 antibodies
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06358430
disease_id_num_tar_ref
491
drug_id_num_tar_ref
1351