gene_symbol
TNFRSF1B
hgnc_id
HGNC:11917
binding_type
receptor ligand recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
rmhTNF binds TNFR2 (and TNFR1) on tumor and tumor-associated endothelial cells, triggering TNF-receptor signaling that induces apoptosis/necroptosis and vascular disruption.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds both membrane-bound and soluble receptor forms
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05755685
disease_id_num_tar_ref
5886
drug_id_num_tar_ref
15973