gene_symbol
EPHA5
hgnc_id
HGNC:3389
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-EphA5 ADC binds EphA5, is internalized, linker is cleaved to release MMAE, which inhibits tubulin polymerization, causing G2/M arrest and apoptosis of EphA5-expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface receptor tyrosine kinase; ADC antigen target
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06014658
disease_id_num_tar_ref
6148
drug_id_num_tar_ref
16662