gene_symbol
UNKNOWN
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
MBRC-101 binds EphA5 on tumor cells, is internalized, and releases MMAE that inhibits beta-tubulin polymerization, causing G2/M arrest and apoptosis; beta-tubulin expression itself is not the cell-surface target for delivery.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Intracellular target of MMAE payload; binds vinca site on beta-tubulin family to inhibit microtubule polymerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06014658
disease_id_num_tar_ref
6148
drug_id_num_tar_ref
16662