gene_symbol
SIGLEC2
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
An anti-CD22 ADC binds CD22, is internalized, and releases a cytotoxic payload that damages DNA or microtubules, triggering apoptosis (with possible bystander effect).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
B-cell surface antigen typically targeted by ADCs in lymphoma
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06202885
disease_id_num_tar_ref
6155
drug_id_num_tar_ref
16681