gene_symbol
MAGEA4
hgnc_id
HGNC:6802
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Engineered TCR T cells recognize MAGE-A4 peptide presented by HLA-A*02 and kill target cells via TCR-activated perforin/granzyme-mediated apoptosis (and Fas–FasL).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Peptide–MHC complex required; HLA-A*02-restricted
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06170294
disease_id_num_tar_ref
516
drug_id_num_tar_ref
1429