gene_symbol
HLA-A
hgnc_id
HGNC:4931
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Engineered T cells kill only cells presenting MAGE-A4 peptide bound to HLA-A*02 via TCR engagement, triggering perforin/granzyme cytotoxicity; HLA-A*02 expression alone is not sufficient.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
TCR recognizes MAGE-A4 peptide bound to this allele
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06170294
disease_id_num_tar_ref
516
drug_id_num_tar_ref
1429