gene_symbol
CEACAM5
hgnc_id
HGNC:1817
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds CEACAM5 on tumor cells, is internalized, and releases the topoisomerase I inhibitor tocentecan, causing DNA damage and apoptotic cell death.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface adhesion antigen on tumor epithelium
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06806046
disease_id_num_tar_ref
518
drug_id_num_tar_ref
1436