gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
TAL-T cells recognize the tumor peptide–HLA-I complex via their endogenous TCRs and directly kill target cells through cytotoxic degranulation (perforin/granzymes) and death-receptor pathways (e.g., Fas/FasL).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Patient-specific polyclonal endogenous TCRs; target is peptide–MHC complex on tumor cells (CD8+ T cell recognition)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06302062
disease_id_num_tar_ref
6220
drug_id_num_tar_ref
16866