gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
TAL-T cells recognize the tumor peptide–HLA class II complex via their endogenous TCRs and directly lyse the presenting cell through perforin/granzyme-mediated cytotoxicity (and Fas–FasL).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Patient-specific polyclonal endogenous TCRs; target is peptide–MHC complex (CD4+ T cell recognition)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06302062
disease_id_num_tar_ref
6220
drug_id_num_tar_ref
16866