gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Cells are selected by CEACAM5 binding; after internalization the payload inhibits topoisomerase I, causing DNA damage and death. Topoisomerase I is not the targeting antigen that dictates which cells are killed.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Intracellular enzyme inhibited by the camptothecin payload (tocentecan)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06806046
disease_id_num_tar_ref
518
drug_id_num_tar_ref
1436