gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The drug binds CD3 on T cells to activate and recruit them; these T cells then kill CD20+ B cells via immune synapse formation and perforin/granzyme release. CD3+ cells are effectors, not killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds the CD3 epsilon chain within the TCR-CD3 complex on T cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06453044
disease_id_num_tar_ref
527
drug_id_num_tar_ref
1455