gene_symbol
HLA-A
hgnc_id
HGNC:4931
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The vaccine primes neoantigen-specific CD8+ T cells, which kill cells presenting the specific neoantigen peptide in HLA-A via perforin/granzyme cytolysis (and Fas–FasL apoptosis); HLA-A expression alone is not targeted.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Allele-restricted peptide loading on APCs; primes CD8+ T cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05153304
disease_id_num_tar_ref
534
drug_id_num_tar_ref
1474