gene_symbol
HLA-DQB1
hgnc_id
HGNC:4944
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The vaccine’s peptides are presented (including via HLA-DQ) to prime T cells; activated CD8+ T cells then kill tumor cells displaying neoantigens on MHC I via perforin/granzyme, not cells expressing HLA-DQ.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Peptide loading on APCs; primes CD4+ T cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05153304
disease_id_num_tar_ref
534
drug_id_num_tar_ref
1474