gene_symbol
CTLA4
hgnc_id
HGNC:2505
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Antibody binds CTLA-4 on target cells; its Fc engages FcγR-bearing effectors (e.g., NK cells/macrophages) to mediate ADCC/ADCP, depleting CTLA-4+ cells such as intratumoral Tregs.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc-enhanced; ADCC-capable
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06300463
disease_id_num_tar_ref
605
drug_id_num_tar_ref
1695