gene_symbol
ITGB2
hgnc_id
HGNC:6155
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Antithymocyte globulin contains antibodies that bind CD18 on T cells, triggering complement-dependent cytotoxicity and Fc-mediated ADCC, and can induce apoptosis, directly depleting the bound cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
polyclonal; repertoire varies by product/lot
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06571825
disease_id_num_tar_ref
654
drug_id_num_tar_ref
1833