gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
HER2-directed ADC binds HER2, is internalized, and releases an intracellular cytotoxic payload that kills the HER2-expressing cell (with additional HER2 signaling blockade).
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Biparatopic binding to HER2 extracellular domains: ECD2 (domain II) and ECD4 (domain IV); promotes receptor internalization and downregulation
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06767800
disease_id_num_tar_ref
82
drug_id_num_tar_ref
209