gene_symbol
CTLA4
hgnc_id
HGNC:2505
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The anti-CTLA-4 antibody binds CTLA-4 on target cells (especially CTLA-4–high Tregs) and engages Fcγ receptor–bearing effector cells to mediate ADCC/ADCP, depleting those CTLA-4–expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Also known as CD152
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06764836
disease_id_num_tar_ref
685
drug_id_num_tar_ref
1911