gene_symbol
UNKNOWN
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Inotuzumab ozogamicin targets CD22 on B cells, is internalized, and releases calicheamicin that binds the DNA minor groove to cause double-strand breaks and apoptosis in CD22-positive cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
sequence-specific binding by calicheamicin payload leading to DNA double-strand breaks
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06387121
disease_id_num_tar_ref
693
drug_id_num_tar_ref
1933