gene_symbol
CLDN18
hgnc_id
HGNC:2039
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Binds CLDN18.2 on target cells and engages immune effectors via Fc to induce ADCC and complement activation (CDC), causing lysis of CLDN18.2-positive cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
On
hla_specific
Off
gated
Off
other_modifier
Gastric-specific A2 isoform of claudin-18
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06206733
disease_id_num_tar_ref
773
drug_id_num_tar_ref
2151