gene_symbol
FKBP1A
hgnc_id
HGNC:3711
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Rimiducid binds FKBP12-F36V on the iCasp9 safety switch in engineered cells, induces caspase-9 dimerization/activation, and triggers the apoptotic cascade, killing the engineered cells.
enzyme_product
On
epitope
Off
variant
On
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Engineered fusion to caspase-9 (iCasp9) safety switch; rimiducid dimerizes FKBP12-F36V to activate caspase-9
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06066424
disease_id_num_tar_ref
791
drug_id_num_tar_ref
2200