gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC binds HER2 (not beta-tubulin), is internalized, and releases MMAE, which binds beta-tubulin to disrupt microtubles and cause G2/M arrest and apoptosis; tubulin expression itself is not the targeting determinant.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
MMAE payload binds the vinca site on beta-tubulin to inhibit polymerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06540729
disease_id_num_tar_ref
810
drug_id_num_tar_ref
2250