gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The mRNA vaccine primes neoantigen-specific T cells. Vaccine-induced CD4 (and CD8) T cells recognize tumor cells presenting the neoepitopes (HLA-II for CD4; HLA-I for CD8) and kill them via TCR-dependent cytotoxicity (perforin/granzyme and/or Fas–FasL), not by the drug directly.
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
CD4+ T-cell targets; HLA class II–restricted; patient-specific multi-epitope
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05916261
disease_id_num_tar_ref
834
drug_id_num_tar_ref
2302