gene_symbol
EGFR
hgnc_id
HGNC:3236
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Cetuximab binds EGFR/EGFRt on target cells and its IgG1 Fc engages FcγR-bearing effector cells to mediate ADCC (and complement activation), depleting EGFRt-expressing cells.
enzyme_product
Off
epitope
Off
variant
On
isoform
On
hla_specific
Off
gated
Off
other_modifier
Truncated extracellular-domain EGFR (EGFRt) expressed on CAR T cells for on-demand ablation
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06447987
disease_id_num_tar_ref
837
drug_id_num_tar_ref
2312